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Desk 1 summarizes the noticed DLTs by cohort. Somnolence, which solved in all but one particular individual, was the only real DLT for MLN8054 given without methylphenidate or modafinil. The onset of somnolence and its severity commonly ended up correlated with dose and Cmax. Mainly because somnolence was thought to be linked to Cmax, the dosing pl… Read More

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